By Andrew Franklin
During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a procedure referred to as affinity maturation. a bunch produces antibodies with successively better affinities with repeated publicity to an analogous antigen, that is the primary wherein such a lot vaccines work.
Affinity maturation will depend on hypermutation, an iterative strategy of mutation at antibody-encoding genes, through confident number of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation can result in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant leap forward got here in 2000 with the invention that activation-induced deaminase (AID) is really required for hypermutation. This was once in 2002 through proof that reduction without delay edits the DNA that encodes an antibody in an activated B mobilephone. a lot has on account that been learnt concerning the biochemistry and legislation of reduction, however the mechanism through which it really is recruited particularly to antibody-encoding genes continues to be enigmatic. realizing this recruitment is clinically major simply because off-target reduction job at oncogenes can result in chromosomal translocations and tumorigenesis.
This publication summarizes the learn on reduction within the context of its valuable position within the affinity maturation of B cells.
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Extra info for Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci
Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin